Career Advice in Pharmacoepidemiology

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  • 1. Career Advice in PharmacoepidemiologyDan Strauss – Klein Hersh InternationalDr. Kourtney Davis - GlaxoSmithKline
  • 2. ContentWho hires epidemiologists?Desired skills/traits in entry-level candidates“What do we really do?” – Dr. Kourtney DavisDaily life, responsibilities, stakeholders, collaboratorsMarketing/Branding YourselfResume building, social networkingInterview Tips
  • 3. BackgroundKlein Hersh InternationalLife Sciences Executive search since ‘98#1 firm in network of 1100 worldwide400 placements annually60-70 per year specific to epidemiology backgroundsEpidemiology, Biostatistics, HEOR, Pharmacovigilance, Risk Management, etc.
  • 4. ContributorsJohn Acquavella (Executive Director, Epidemiology – Amgen)Terri Madison (VP, Epidemiology & Risk Management – Excenda)Syed Islam (Senior Director, Pharmacoepidemiology – Abbott)Dan Mines (VP, Safety Surveillance & Epidemiology – HealthCore)Gregory Daniel (VP, Gov’t& Academic Research – HealthCore)Crystal N Holick (Director, Safety & Epidemiology – HealthCore)William Blumentals (Head, Epidemiology for Virology – Roche)Andres Gomez (Executive Director, Epidemiology – BMS)Nancy Santanello (VP, Epidemiology – Merck)Robert Reynolds (VP, Epidemiology – Pfizer)Jamie Geier (Director, Epidemiology – Pfizer)Jesse Berlin (VP, Pharmacoepidemiology – J&J)Andre Araujo (VP, Epidemiology – NERI)
  • 5. Companies with EpidemiologistsPharmaceuticals, Medical Device, Biotech (Industry) GSK, Pfizer, Amgen, J&J, Abbott, Roche, BMSContract Research Organizations (CRO) Covance, Quintiles, PAREXELConsulting and Vendor CompaniesXcenda, Healthcore, SciMetrikaPharmaceutical Benefits Management (PBM)MedCo, Express ScriptsGovernment, Regulatory, and Academia -State Government, CDC, FDA, NIH, NERI, Universities
  • 6. Location of Industry Positions Major Pharma/Biotech HubsNYC Metro, Philly, Boston, San Fran, Outside USA12 of the top-20 earning pharma companies worldwide have offices within 100 miles of NYC.Boston/Cambridge increasingPhiladelphia remains steadyChicago/Mid-WestNC has Pharma and large CRO headquartersWest Coast (San Fran, San Diego)
  • 7. Industry Salary InformationWill depend on locationGeographic location AND location within companyTHERE IS MORE THAN JUST SALARY!!!!!Target Bonus %, Long-Term Incentives, Sign-on, etcCulture, Growth OpportunitiesStarting Salaries from $60k-85k for an MPHStarting Salaries from $70k-110k for a PhDContract/PermanentIf it is contract, what are the terms?
  • 8. What Hiring Managers Want to SeeStudy design / methodological skillsLogical approach to refining research questions – LOGICAL THINKERSMatching designs and data sources to questions-- fit for purposeStatistical AnalysisFamiliarity with SAS and other languages (STATA, SPSS, R)Can you show how you used it?USE OF LARGE DATASETSHealthcare claims databases (private and public), disease cohorts, population-based surveysAbility to manage the dataHave you done one of these studies?Independent, observational studyAre you able to briefly describe the study aims, outcome, and impact?
  • 9. What Hiring Managers Want to SeeExpertise/Knowledge of at least one Therapeutic AreaHave you published independent or collaborative research?What studies have you led? Grant proposals written and/or funded?Any type of clinical knowledgeClinical Education (MD, RPh, RN, PharmD)Intro to Pharmacology for non-medical professionalsPublications and scientific presentationsWere you the first author of published paper?Did you publish your thesis/dissertation?Have you made oral or poster presentations at international conferences?
  • 10. What Hiring Managers Want to SeeWhat EPIDEMIOLOGY activities did you do during your program?A study with your professorAn R.A. focused on epidemiology research or courseVolunteering – research, clinical, etcTeaching introductory classesAre you following the current trends?Comparative Effectiveness, Health OutcomesSafety Studies (Risk Management, REMS)Company infoMergers/Acquisitions, Success, TA, etc.
  • 11. What Hiring Managers Want to SeeCommunication SkillsWritten and OralDiverse audiences (e.g. to non-epidemiologists)Influencing and negotiation Leadership QualitiesManaging programmers and contract research support staffExternal issues – CRO, Consulting, Regulations, etc.PersonalityDemonstrated teamwork and success in matrix environmentKeeping the “client” happy Internal or externalResilience
  • 12. “What do we really do?”Dr. Kourtney Davis, PhDSenior Director, Worldwide Epidemiology - GSK
  • 13. Who is WWEpi @GSK? Part of Quantitative Sciences (QSci) in Medicines Discovery and Development (MDD), GSK Research & DevelopmentOffices in US (RTP and Philadelphia) and UK (Stockley Park)Combined staff of ~60 epidemiologists, programmers/analysts, administrative staff WWEPI MissionProvide population-based evidence on disease and treatment to influence decision making—from discovery through drug development to medical practice. 13
  • 14. Epidemiology at GSK - direct input to assets and strategyCommit to targetTractable hit (CEDD entry)Candidate SelectionApproval for FTIHProof of Concept Commit to Phase 2bCommit to Phase 3Commit to launchLabelingChangesDisease/Target SelectionClinical Development PlanningRisk-Benefit Assessment
    • Disease Epidemiology
  • 15. Incidence, prevalence, mortality
  • 16. Co-morbidity patterns
  • 17. Disease risk factors
  • 18. Natural history of disease
  • 19. Recurrence or progression patterns
  • 20. Genotype-phenotype distributions
  • 21. Disease marker validation
  • 22. Opportunity Assessment
  • 23. Trends, forecasts in patient populations
  • 24. Medical need at population or sub-population level
  • 25. Understanding Treatments
  • 26. Diagnostic and treatment patterns
  • 27. Treatment effectiveness
  • 28. Planning Clinical Programs
  • 29. Size and location of patient population
  • 30. Identification of high-risk sub-populations
  • 31. Assessment of inclusion/exclusion criteria
  • 32. Placebo response
  • 33. Outcome measures
  • 34. Safety Issues
  • 35. Background rates of safety outcomes and lab abnormalities
  • 36. Post-marketing safety studies
  • 37. Pregnancy registries
  • 38. Electronic health records
  • 39. Securing Regulatory Approval & Post-Licensure Commitments
  • 40. Dossiers
  • 41. REMS
  • 42. Risk management plans
  • 43. Formal studies of drug safety and registries
  • Description
    1. Career Advice in PharmacoepidemiologyDan Strauss – Klein Hersh InternationalDr. Kourtney Davis - GlaxoSmithKline 2. ContentWho hires epidemiologists?Desired skills/traits…